Delivery of antibacterial nanoparticles into dentinal tubules using high-intensity focused ultrasound

Shrestha A, Fong SW, Khoo BC, Kishen A.

Department of Restorative Dentistry, National University of Singapore, Singapore.

INTRODUCTION: High-intensity focused ultrasound (HIFU) produces collapsing cavitation bubbles. This study aims to investigate the efficacy of collapsing cavitation bubbles to deliver antibacterial nanoparticles into dentinal tubules to improve root canal disinfection. METHODS: In stage 1, experiments were performed to characterize the efficacy of collapsing cavitation bubbles to deliver the miniature plaster beads into a tubular channel model. (more…)

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